Browsing by Author "Koca, Irfan"
Now showing items 1-5 of 5
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Acyl Thiourea Derivatives Containing Pyrazole Ring Selective Targeting of Human Aurora Kinases in Breast and Bone Cancer
Ozgur, Aykut; Yenidunya, Eren; Koca, Irfan; Tutar, Yusuf (BENTHAM SCIENCE PUBL LTD, 2015)Several oncogenic pathways may lead to cancer. Pharmaceutical research develops efficacious compounds to inhibit these pathways. Current inhibitor drugs may block several pathways simultaneously but cause adverse and side ... -
Design and synthesis of pyrimidinyl acyl thioureas as novel Hsp90 inhibitors in invasive ductal breast cancer and its bone metastasis
Koca, Irfan; Ozgur, Aykut; Er, Muhammet; Gumus, Mehmet; Coskun, Kubra Acikalin; Tutar, Yusuf (ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2016)Invasive ductal carcinoma is the most common breast malignancies tumors and has tendency to bone metastases. Many oncogenic client proteins involved in formation of metastatic pathways. Stabilization, regulation, and ... -
Design, Synthesis, and Evaluation of Heat Shock Protein 90 Inhibitors in Human Breast Cancer and Its Metastasis
Gumus, Mehmet; Ozgur, Aykut; Tutar, Lutfi; Disli, Ali; Koca, Irfan; Tutar, Yusuf (BENTHAM SCIENCE PUBL LTD, 2016)Background: Despite development of novel cancer drugs, invasive ductal breast carcinoma and its metastasis are still highly morbid. Therefore, new therapeutic approaches are being developed and Hsp90 is an important target ... -
A Novel Approach to Inhibit Heat Shock Response as Anticancer Strategy by Coumarine Compounds Containing Thiazole Skeleton
Koca, Irfan; Gumus, Mehmet; Ozgur, Aykut; Disli, Ali; Tutar, Yusuf (BENTHAM SCIENCE PUBL LTD, 2015)Inhibition of the Hsp90 function is an essential therapeutic approach and several inhibitors were designed as anti-cancer agents. These inhibitors are ATPases and they aim to deregulate Hsp90 folding function. ATPase ... -
Synthesis and anticancer activity of acyl thioureas bearing pyrazole moiety
Koca, Irfan; Ozgur, Aykut; Coskun, Kubra Acikalin; Tutar, Yusuf (PERGAMON-ELSEVIER SCIENCE LTD, 2013)In this work novel organic based compounds, acyl thiourea derivatives were synthesized and their anticancer activities were investigated. A new series of acyl thiourea derivatives containing pyrazole ring were prepared in ...